H2N2V1, Main, Exploration, bibRecord, 001970

Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong

Identifieur interne : 001970 ( Main/Exploration ); précédent : 001969; suivant : 001971

Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong

Auteurs : Nan Nan Zhou ; Kennedy F. Shortridge ; Eric C. J. Claas ; Scott L. Krauss ; Robert G. Webster

Source :

Journal of Virology [ 0022-538X ] ; 1999.

RBID : PMC:104101

Abstract

The H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of “internal” virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC104101

PubMed: 10074191
PubMed Central: 104101

Affiliations:

Le document en format XML

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<author><name sortKey="Zhou, Nan Nan" sort="Zhou, Nan Nan" uniqKey="Zhou N" first="Nan Nan" last="Zhou">Nan Nan Zhou</name>
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<front><div type="abstract" xml:lang="en"><p>The H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of “internal” virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.</p>
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Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong

Rapid Evolution of H5N1 Influenza Viruses in Chickens in Hong Kong

Source :

Abstract

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